With more than 20 years of experience in clinical research and development covering Phase 1-4 studies, clinical pharmacology, precision medicine, and 10+ years of experience in biomedicine research and development including immunotherapies, antibodies, cell therapies, oncolytic viruses, and RNA therapies. JMSS has accumulated extensive expertise in medical science service: covering pipeline selection, scientific writing, medical illustration, and clinical strategy optimization.
20년 이상의 임상 연구 및 개발 경험을 보유하고 있으며, 이는 1상부터 4상까지의 임상시험, 임상약리학, 정밀의학을 포함합니다. 또한 10년 이상 면역치료제, 항체, 세포치료, 종양용해바이러스, RNA 치료제 등 바이오의약품 연구 및 개발 경험도 갖추고 있습니다. JMSS는 풍부한 의료 과학 서비스 전문성을 축적해 왔으며, 그 범위는 파이프라인 선정, 과학적 문서 작성, 의료 일러스트레이션, 임상 전략 최적화 등을 포함합니다.
Our Clients
Publications
Pancreatic Adenocarcinoma Up-Regulated Factor (PAUF) Transforms Human Monocytes into Alternative M2 Macrophages with Immunosuppressive Action. Int J Mol Sci. 2024 Oct 27;25(21):11545.
CTHRC1 induces pancreatic stellate cells (PSC) into myofibroblast-like cancer-associated fibroblast (myCAF). Cancers (Basel). 2023 Jun 27;15(13):3370.
PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway. Int J Mol Sci. 2022 Sep 27;23(19):11414.
PAUF as a Target for Treatment of High PAUF-Expressing Ovarian Cancer. Front Pharmacol. 2022 May 6;13:890614.
Long Term Effectiveness and Safety of Tafluprost, Travoprost, and Latanoprost in Korean Patients with Primary Open-Angle Glaucoma or Normal-Tension Glaucoma: A Multicentre Retrospective Study (The LOTUS Study). J Clin Med. 2021 Jun; 10(12): 2717.
Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase. Cancers (Basel). 2020 Jan 17;12(1):228.
A randomised phase 2b study comparing the efficacy and safety of belotecan vs. topotecan as monotherapy for sensitive-relapsed small-cell lung cancer. Br J Cancer. 2020 Nov 16.
Evaluation of Two EGFR Mutation Tests on Tumor and Plasma from Patients with Non-Small Cell Lung Cancer. Cancers (Basel). 2020 Mar 26;12(4):785.
A Highly Sensitive Next-Generation Sequencing-Based Genotyping Platform for EGFR Mutations in Plasma from Non-Small Cell Lung Cancer Patients. Cancers (Basel). 2020 Nov 30;12(12):3579
Characterization of Oncolytic Vaccinia Virus Harboring the Human IFNB1 and CES2 Transgenes. Cancer Res Treat. 2019 Aug 6.
Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus. Drug Des Devel Ther. 2018 Aug;12(8):2467-2474.
Genetic analysis of sick sinus syndrome in a family harboring compound CACNA1C and TTN mutations. Mol Med Rep. 2018 May;17(5):7073-7080.
Prognostic significance of hypoxia inducible factor-1α expression in patients with clear cell renal cell carcinoma. Mol Med Rep. 2018 Mar;17(3):4846-4852
A pharmacogenomic Study on the Pharmacokinetics of Tacrolimus in Healthy Volunteers Using the Affymetrix DMET Plus Platform. Pharmacogenomics J. 2016 Feb 16
The Influences Of SLCO1B1 and ABCB1 Genotypes and CYP3A4 Inhibition on the Pharmacokinetics of Simvastatin in Healthy Volunteers. Pharmacogenomics. 2017 Apr;18(5):459-469
Effects of Drug Interactions and CYP2D6 Genotypes on Venlafaxine Pharmacokinetics: An Exploration of Biomarkers for Venlafaxine Pharmacodynamics. Psychopharmacology. 2015 Jun;232(11):1899-909
Population pharmacogenetic-based pharmacokinetic modeling of efavirenz, 7-hydroxy- and 8-hydroxyefavirenz. J Clin Pharmacol. 2014 Jan;54(1):87-96
Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl-metabolites: exploration of a novel CYP2B6 phenotyping index. Br J Clin Pharmacol. 2013 Jan;75(1):244-53.
Effect of HNF4α Genetic polymorphism G60D on the pharmacokinetics of CYP2D6 substrate tolterodine in healthy Korean subjects. Pharmacogenet Genomics. 2013 Mar;23(3):175-9.
A pilot study on intravesical administration of curcumin for cystitis glandularis. Evid Based Complement Alternat Med. 2013;2013:269745
Rapid and Simultaneous Determination of Efavirenz, 8-Hydroxyefavirenz, and 8,14-Dihydroxyefavirenz Using LC–MS–MS in Human Plasma and Application to Pharmacokinetics in Healthy Volunteers. Chromatographia. February 2011, Volume 73, Issue 3-4, pp 263-271
Effects of Ginkgo biloba extract ingestion on the pharmacokinetics of talinolol in healthy Chinese volunteers. Ann Pharmacother. 2009 May;43(5):944-9
Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers. Xenobiotica. 2009 Mar;39(3):249-54.
Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation. Eur J Clin Pharmacol. 2009 Apr;65(4):403-9.
Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males. Clin Chim Acta. 2006 Nov;373(1-2):99-103